The 6.8L V10 comes in 2 different varieties. The older one are 2 valve and the newer ones are 3 valve
(except on the Econline/E-Series chassis which kept the 2 valve). Big difference in horsepower/torque numbers.
The following were the biggest issues.
Wikipedia wrote:
2-valve 4.6 L, 5.4 L, and 6.8 L engines found in many 1997-2008 Ford, Lincoln, and Mercury vehicles may have aluminum cylinder heads with threads for spark plugs that are stripped, missing, or otherwise insufficiently bored out.
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3-valve 5.4 L and 6.8 L engines built before 10/9/07 and 3-valve 4.6 Ls built before 11/30/07 found in many 2004–2008 Ford, Lincoln, and Mercury vehicles have an issue with difficult-to-remove spark plugs, which can cause part of the spark plug to become seized in the cylinder head.
The second issue is easily resolved by using an impact wrench on the spark plugs while they are hot.
The 6.2L does not make as much torque as the older V10 but it works well with the current 6 speed transmission and get better fuel economy.