I would probably leave the RV at home and take the car.
As far as possibly staying in a motel/hotel: I've never in all my years of travel had a bad encounter staying in a hotel and I still always look for the low priced ones. Sure some are not as nice as others, I just try to keep it all in perspective. I'm in this hotel/motel room to sleep use the bathroom and take a shower. I don't really care what it looks like inside. I don't bring a black light to look at the comforter/bedspread, and I don't really think about it. I'm sleeping under it and the blanket and the sheet, I'm not putting it in my mouth and chewing on it. I have never seen bedbugs and yes I always check. It's just a non issue for me.
The fuel prices (almost $4 a gallon in California) favor the car.
The ability to get on the road, to accelerate into traffic, to put on my signal and easily go around that slow moving truck, trailer, or RV favor the car.
Yes the spare room for at the house could be a problem, but that all depends. How much do I anticipate being in the house vs how much will I be out and about? Excluding my family how many people are in the house besides the owner? If only one bathroom I'd probably take the RV, but not always.
All in all I would probably take the car.