I put a 2x4 block under the U-bolts and use a stubby bottle jack under that. That way the trailer doesn't tilt anywhere near as much compared to jacking up the frame. If you jack one side up, whether it's 1 or 2 wheels, make sure to use jack stands for safety and in case the jack doesn't hold and also make dang sure the wheels on the opposite side are properly chocked. You might also want to put the stab jacks down. If you lift the frame up, jacks need to be as close as you can to the wheel so you don't damage the frame.
You can easily take one wheel off at a time using a tire ramp or your leveling blocks. Taking one tire at a time to a shop could be a slow PITA, especially if you have to go any distance. Good method for changing a flat on the side of a road somewhere.
Easier way is to just take it into a tire shop and let them take care of getting the wheels off the ground. Some shops might put it on a hoist and get all wheels off at once. If aluminum rims, don't let a shop use an impact gun because they can over-torque the bolts. Torque the bolts up yourself to the specified torque (typically 90 - 100 ft/lbs but can be higher.) and check the torque at the intervals as per your owners manual.
Goin' camping this weekend for 1st time this year. I'm all jacked up! :)

