I'd be shocked to ever see any of issues Ford experienced with the 6.0 or the 6.4 International motors ever again.
The entire point of the in-house venture was to get AWAY from the class-action lawsuits, horrible PR, bad reviews/tests, people jumping ship with brand & image, etc.
I first saw this thing at the 2010 World Equestrian Games in Kentucky. They rolled out an entire stage and bunch of trailers with engines, parts, engineers on-hand, and a full cut-away of the engine on a rotating stand, etc. At the time it was HOT off the press too.
I was very impressed. The "inverted" design was something BMW had recently decided to do with the new M5 engine (and many subsequent designs) - tucking the turbos into the V creates much higher efficiency with regards to piping, heat/energy/pressure recovery, etc. It also tends to trap heat in a confined area while the rest of the (cooler) plumbing is purely induction. Really a brilliant design, both BMW and Ford seem to have had great success with it.
Like others have said, I think it allows for better access to common wear items, sensors, etc. as well. Plus the temperature separation would tend to increase reliability as well, as high temps are limited to a small area that's easy to shield.
Then again at the end of the day, the core Cummins engine still has ~40% fewer moving parts, and there just isn't any way around that with a V engine. I'm sure internal parts aren't a problem (usually) but you still have the external components. Space is also an issue if you plan on working w/ the thing yourself.
Let's put it this way - of all the people I know who own either platform, they both SWEAR by it and think it's better than the other. I don't really know anyone that regrets whatever truck they spend $60k on. At least they'd certainly never admit it. ;)
