Yes, they're worth the hassle.
I prefer using a macerator pump to a tank in the truck bed, rather than towing a wastewater tote on the ground - dump stations aren't always close by, and terrain not always suitable for pulling those totes along. I started off with a 42g Barker tote with pneumatic tires.
I had Husky Portable Containment build me a custom 95g freshwater bladder and a 165g wastewater bladder, that were configured to sit side by side in the free space in my truck bed at the time. And after trying out several pumps, I ended up with a Sanicon Turbo permanently attached to the rig and camlock fittings on 25' of 1.5" layflat hose. That setup made short work of pumping out, then I could just take the pickup to the dump station and empty it with the conventional 3" hose. The bladder, regardless of how you choose to fill it, takes up a lot less room stored than the tote.
For what it's worth, I use a Milwaukee transfer pump for the freshwater side, and with that much water, carry a little pressure washer with me that you can see in the photo.
We also have an off-the-shelf 45g bladder for freshwater and a few collapsible 5g jugs for our truck camper. And a composting toilet that lets us combine the grey and black tanks for 83g of grey capacity. Lots of ways to go about it.
