Which truck / camp rig is taller (to the top of the camper including roof top equipment) and hauling the same camper: 1. F450 Cab and Chassis with a flat bed, or 2. F450 with pickup style box?
Look at the upfitter guide, it will tell you everything you need to know. The wheels and wells for them aren't the problem, they are in the same place whether CC or pickup frame. The problem is the frame itself. With wheel wells on the flatbed - and this is certainly not unheard of - you can get it lower, but very hard to get as low as a pickup.