I live in Hebo, OR and travel Hwy 22 a lot. Whether to take Hwy 18 or Hwy 22 depends on which way you are headed on Hwy 101. If going South take hwy 18, North take Hwy 22.
Hwy 22, as already said, is a winding road but very doable. It is a commerce highway so you will have log trucks, hay trucks, and freight trucks on the road too.
Bicycles are only an issue in May when they have the Reach the Beach fund raiser which takes the riders from Portland to Pacific City.
I use Hwy 22 to travel from Hebo to Woodburn Dragstrip in my 40 ft. motorhome towing my 24 ft enclosed trailer.
Paul
Paul & Sandy
2018 Tiffin Allegro Bus 40AP
'56 Ford Customline Victoria
'62 Chevy Impala SS 409/4spd
U.S. Army Retired
Cloverdale, OR