2002 E350 Parking Brake

Although $2,200 sounds quite high, it's probably more work than the simple adjustment . If....IF it's a removable drum it's not that bad to take apart and replace the shoes etc. If it's one piece, then yes it's more work due to the floating axle and the need to remove the axles etc. The reason I say it's more than a simple adjustment, is because of the circumstances. You stated it was driven with the parking brake engaged, when I was running a service department at a Ford dealer I would never had suggested simply adjusting the parking brake after that scenario. You cannot see how much heat and damage was done without taking it apart and inspecting the linings and drums. I would also suggest taking it to a Ford dealer or local truck shop, but I would fully expect a complete tear-down and most likely a lining replacement at best. Good Luck !