The E450 are more difficult.
They hid the vacuum tank and check valve inside the AC housing.
The dealer will discharge the AC remove the lines and housing to get to it.
They will charge approx $900 labor and around $40.00 for parts.
Going to defrost is the default setting.
There are a number of "work arounds" on the web especially the Ford Forums.
A $19.00 vacuum tank with built in cheek valve from most auto parts stores and
some vaccum line is the fix.
The connector from the engine to the vacuum tank is above the oil filler under a clip. Factory lines are small and hard.
The vacuum line can be feed back into the cab by starting in the cab with a piece of heavy wire. Remove the rubber gimlet that the vacuum hose now goes through and push the wire into the engine compartment. It will come out between the fender and the AC housing. Pull the 1/8" vacuum hose carefully back into the cab.
You can place the new tank/valve assembly anywhere you find space either under the hood or behind the dash. The dash panels snap off and there is a metal framework behind them.
Hook the vacuum line end into the vacuum motor on the left at the heater door. Hook the other end and the Vacuum tank hose. Then the other tank inlet to the motor lead above the oil filler cap.
Secure the tank.
If you do not use a vacuum tank / check valve, you will lose vacuum on hills and under acceleration.
This is a common problem.
Lots of info on the web.