We use the MIX setting "a lot" in our E450 motorhome's cab to keep cool air coming out at our feet at the same time as cool air coming upward and flowing down over us from the front windshield vents - this is far superior to the air conditioning blasting directly out at our face and body from the dash vents.
However, our motorhome's floor does not get that hot anyway ... because for some reason there are heat shields installed underneath in the front blocking heat transfer from the V10's exhaust up to the cab floor. Here are photos of the driver's side heat shield (upper photo) and passenger's side heat shield lower photo):


A Ford mechanic said that the shields were not standard Ford cutaway van items, so I assume that Winnebago had them custom-installed by Ford or some third party before building the motorhome (Itasca) onto the E450 chassis.
By the way, our Ford E450's temperature gauge has never moved into it's high temperature area under any conditions - so I assume that means that the engine and transmission temperatures are staying within safe operating zones. We run the air conditioning as much as we want as high as we want in the MIX or other settings whether pulling up long mountain grades in scorching temperatures or sitting idling on the blacktop in fast food parking lots for minutes on end in scorching temperatures.
I consider the E450's engine/transmission cooling system as outstanding and definitely one of it's strong points. As a indication of this, the E450's transmission cooling system actually takes about 5 more quarts of fluid than that of the E350 transmission's cooling system.
I would recommend that the OP first look into getting metal heat shields installed above the exhaust pipes under the cab floor and then using the MIX air conditioning vent setting much more - then maybe trying heat insulation schemes only as a last resort.