The E450 is also going to have increased transmission cooling (for driving up any grade in any hot temperature with full A/C on and no tranny heating), increased brake size (for more reliable braking anywhere anytime and longer intervals between brake jobs), and a wider rear stance in it's duallies (for improved laterally stability on curves and in high cross-winds).
The Chevy 4500 probably has the same advantages over the Chevy 3500, but it's only offered with a V8 gas engine ... as opposed to Ford's superb V10 gas truck engine and 5-speed (6 speeds internally) fully computer controlled TorqueShift transmission. The E450 chassis under our 24 foot Itasca has easily pulled us at full highway speeds up to and along roads over 9000 feet ...it's overall power and delivered-to-the-ground torque are superb. It idles ultra smooth and vibration free (due to 10 cylinders) and we even idle it sometimes to charge the coach battery bank when drycamping ... we hardly know it's running when it's doing this and any camping neighbors can't hear it idling.
Soon we will be replacing the Ford OEM shocks with this high technology Koni shock to help take the sting out of highway cracks (while still retaining lateral rolling control) in the rear of our over-kill E450 chassis carrying only a 24 foot Class C:
http://www.koni-na.com/uploads/KONI_E350450_Cons_PR.PDF