When we pulled our fivers we installed a 60 gallon auxiliary diesel fuel tank. Never had to worry about stopping for fuel like most people. Together with the main tank I had over 90 gallons. We could fill after pulling over for the night or after we setup camp. never worried about finding a gas station. That took some pressure away from the driving.
Now the MH has 100 gallons so one can be selective where they fuel up. Truck stops are the best. You need do a little research as to where they're on your trips or just make sure there is around half a tank of fuel before looking for a spot. If using those, and have a diesel pusher, space to manuever isn't a issue.
As far as driving comparison between the TT - fiver - MH, and of course it's just my experience the MH is way less stressful to drive. If backing into a campsite, comparable lengths, the fiver truck combo would have about the same pivot points as a motor home, but there is more truck out in front in comparison ( length in front of MH front wheels, and length from the rear wheels on a pickup to the front). So I don't see it being an advantage going to the pickup truck if trailer lengths are equal. I can tell you the MH is way easier to back up ( if needed). Steering response is immediate compared to a fifth wheel hitch.
If the length is he only thing eating at you, then you made a mistake. But, think of what it really is that gets at you. Can you do something to help eliminate those issues ( larger fuel tank). If not, go test drive a few MH's ( if you get a gasser your not going to be able to use truck stops).