Even with a motorized rig if you don't winterize between outings you will still need to prevent the potable water system from freezing and bursting of pipes. The coach doesn't need to be 72 degrees just warm enough to stay above 32.
When parked at a camp site keeping warm requires a bit of preplanning so you don't burn thru a tank of propane before it's time to head for home and there are tricks that help. Cover the windows with reflective foil backed insulation in particular the windshield. Using electric space heaters if on CG power will slow propane use but you may still need to run the propane it the tanks are heater with air. Keep the slides in to reduce the volume of air to heat and a closed slide might have a better seal to prevent drafts.
The key is the coach you choose. Double pane windows and electric heated tanks will go a long way to make an outing more enjoyable. Heat pumps are a good option but efficiency drops as the outside temps drop. Towing isn't any different summer or winter. It is the reverse of what you'll be used too concerning weight and effects. The coach is may times heavier than a tow car. If you have the budget a diesel rig with an
AQUAL HOT system is the way to go.
One thing to keep in mind, a coach more or less has no undercoating to prevent rust from road salt exposure. You will to stay on top of any corrosion that pops up. Not difficult as long as you get it early.