Have done it LOT for years. Since I'm retired, I typically leave home early on a Friday morning and the odd time on a Thursday to increase the chances of getting a better site. We are Thousand Trails members and have 3 CGs nearby that I often tow our TT to and DW comes down later in her car after she's off work. It's nice to beat the after work crowd that show up in the evening.
Never have problems of any kind but it is easier sometimes when DW is there to be a spotter. There's often fellow campers around that want to help you back in. Thing is, they often don't help and they don't know the correct hand signals and I sure don't want to smack into a pedestal or tree limb. Can be downright annoying sometimes. Only spotter I trust is DW.
Many tow TTs and drive RVs all over the country solo, big and small, including women with all types of RVs. While on the Oregon coast, we camped next to a lady in her 70s from New York in a HUGE MH. Pretty impressive for anyone at that age and by themselves.
Farthest I've been alone is about 300 miles (one way)and zero issues. That's when it's nice to have the dog riding shotgun with me. I've gotten some great smiles from drivers who pull up beside me at a stoplight and see the passenger, lol. If there's a lot of turns onto different roads and highways, I make a sketch of the route and with exit numbers and keep it in sight on the dash. Have a GPS also that helps.