Why?
The RV pipes can take 150 psi of water easily. Water does not compress, air does!
45 psi of air at the nozzle will not be 45 psi of air pressure once in the water pipe system, it will drop way lower because the pipes are way bigger than the air hose. If the water heater tank is empty then psi will drop way way down (maybe 5psi) and as long as there is no blockage on the downstream side of the pipe then air pressure will not build up much at all.
I would imagine you could blow in 300psi and nothing would happen, the drop in psi from 300 at the air nozzle to what it would be in the bigger longer water pipes would be enough of a drop to not be an issue.
Again, air will compress, unlike water that has nowhere to go, air will compress in itself so need nowhere to go.
Very likely your air compressor cannot give enough psi to do any damage to anything in your RV.
I do not recommend using a 100 gallon commercial 300 psi air compressor to blow out your air lines, but if you do then just do short burst of air, not a long steady flow of high psi air just to be safe, because i have not done testing with air in pipes, but I do know those same water pipes are used for these 300psi air compressors.
I guess the bigger concern is your faucets or the stop-valve on your water pump.