This isn't going to be helpful, but my answer is, "It Depends". It will depend on where you camp and how well the coach is insulated. My last fifth wheel had one A/C unit and it did well, even in full sun in Florida. I purchased a new coach that was about five feet longer and had two more slides than the first one and elected not to get a second AC unit.
Our first summer trip was to a campground in the Florida Panhandle. We were in full sun and it was close to 100 degrees. When I set the coach up, the interior temperature pegged the thermometer. We left and went to dinner and were gone more than an hour. When we returned the thermometer was still almost pegged. The coach didn't cool off enough for the AC to cycle until around 5:00 a.am. the next morning.
The AC could only keep the coach about 15-20 degrees cooler than the outside temperature. We purchased a second AC unit as soon as we got back home. I don't usually use both, but it's nice to have it available when it gets really hot.