Do you have a programer/chip on your 425 ISL?
You maybe running too hard, over heating the fuel in the head as the return fuel is returning to the tank, this will cause Asphalting, and clog filters.
Does you oil quantity go down as you drive. If so, you can have a leaking "O" ring that separates the oil from the return fuel in the head.
Have your shop call Cummins technical get them involved, they will tutor the shop thru the repair process.
Do not allow the shop start throwing parts at this problem, none of cummins injection pumps can cause this, and they are huge expensive.
You either picked up a load of bad fuel, or have oil or combustion products getting into the return fuel.
Have you ever seen any black jelly like substance in the filter cans when you change filters? (that would be algae )
A loose injector will allow combustion products to enter the return fuel when combustion occurs. IT simply by-passes the copper gasket at the bottom of the injector, enters the return fuel.
A leaking injector "O" ring will allow oil to enter the return fuel, but usually shows as high oil usage.
Both will eventually clog a filter. quickly at first. -- ( that, I still don't understand)
PM me for all we have done to cure our problem.