The cab appears unchanged other than the instrument cluster and steering wheel, which will be common with the F-series. This allows for adaptive cruise, lane departure warning, auto emergency braking etc.
The 6-speed transmission is being retained for the motorhome chassis (E-series and F53 stripped chassis). I suspect this is due to a combination of: 1) The tallest ratios of the 10 speed being unusable in a motorhome, and 2) the lowest ratios making too much torque for the existing drivetrain, which is unchanged. It will gain hill-start assist and "neutral idle" to reduce fuel consumption in town.
It will have an optional dual alternator, with 397 amps available, so with modern lithium battery packages, you may be able to skip on a gen-set.