My position on the Sprinter chassis does not require ever having driven one ... as how a Class C handles is only part of the criteria. IMHO, the SRW Sprinter 2500 has no business being under a Class C of any length. As far as the DRW (3500) Sprinter is concerned - unless they now have a heavy duty DRW 4000 series - I personally wouldn't want a Class C that stresses the chassis under it so close to the maximum for the chassis itself and it's systems. It would be similar to the wear and tear from driving a delivery truck near it's full rated load week after week.
The 4500 Chevy and E450 Ford chassis provide a lot more capacity overhead to deal with Class C rigs from 23 to 26 feet. What that means is such things as: Longer brake life per brake set, an overly strong frame that helps to maintain a flatter coach platform plane for off-pavement travel to/from campgrounds, probably more reliable cooling for such situations as full A/C use up any grade in any ambient air temperature conditions, a wide rear track stance for a more substantial "driver and passenger feel" in high cross winds, on highway curves, and for when tipped while driving on rutted gravel or dirt roads, a larger diameter drive shaft for maybe less vibration at certain speeds, and a lower rear differential ratio for better towing up grades.
Also, nearly all Sprinter based Class C motorhomes I see seem to have minimal ground clearance overall. My BIL had a Sprinter Class B motorhome for awhile and I had to crawl under it once to repair a sewer valve. It was a real squeeze moving around down there to do anything ... definitely lower than our E450 Class C. The coach sidewalls were even lower to the ground. This low ground clearance will further limit use of them in many off highway camping situations.
