The 4R100 transmissions do not react well to getting too hot but will run a long time IF you keep that in mind. #1 Install a good transmission temp gauge. While you are at it adding a boost and EGT gauge all in a pillar mount is not a bad idea. By the time the factory gauge starts to head for the red zone you have probably cooked your trans. Much over 200-220 is the "take your foot off the throttle" range. At 145K I know I'm on borrowed time but I watch the gauges, keep out of the red on trans and EGT and cross my fingers. On a related note if you ever push the OD Off button on the end of the gear selector and your gauges die and no throttle don't panic. I thought I'd killed my transmission. You just blew fuse #45 when the wires where the lever meets the column shorted out. Happened to me. Replaced fuse, got home and found a great write up on Dieselstop.com. and a couple hours and some insulation, problem solved. Always carry an extra CPS sensor, a spare fuel filter and a belt. If your do roast your trans it is a good time to replace the cooler with one from a 6.0.