That area is infamous for cartel problems. Normally not a problem for tourists. You will need Mexican Insurance. Not a free zone so car and Motorhome permits are required. These days boondocking is not recommended. Personally, I would not travel to that area. Not the same a s driving down Highway 15. Here is the US travel advisory:
Nuevo Casas Grandes Area (including Nuevo Casas Grandes, Casas Grandes, Mata Ortiz, Colonia Juarez, Colonia LeBaron, and Paquime): U.S. government employees may only travel to the Nuevo Casas Grandes area during daylight hours through the United States, entering Mexico at the Palomas U.S. Port of Entry on New Mexico Route 11 before connecting to Mexico Federal Highway 2, and subsequently Federal Highway 10, to Nuevo Casas Grandes. Employees are permitted to stay overnight in the cities of Nuevo Casas Grandes and Casas Grandes only.
Keep in mind that often these advisories can be overprotective.