I often hitch up the night before we leave with the trailer still plugged into 30 amp service to power the residential fridge as well as plugged into the truck. The hot lead on the Ram's 7-pin Pollak receptacle is hot with the truck on or off. No problems at all doing this.
The battery isolation relay that some trucks use in the B+ (pin 4) circuit to the trailer is there to prevent the trailer from drawing down the truck's batteries if left connected for extended periods of time with the truck's alternator not running and the trailer not plugged into shore power. In my case, the net effect as far as the truck is concerned is that the power converter in the 5th wheel is keeping the truck's batteries topped up just like a battery tender would.
Rusty
2014.5 DRV Mobile Suites 38RSSA #6972
2016 Ram 3500 Dually Longhorn Crew Cab Long Bed, 4x4, 385/900 Cummins, Aisin AS69RC, 4.10, 39K+ GCWR, 30K+ trailer tow rating, 14K GVWR
B&W RVK3600