Absolutely. We boondock en route and we have a fifth wheel. The size of your rig doesn't make a difference. What the motorhomers like is that they don't have to leave their vehicle when they stop, those of us with towables, do.
2011 Bighorn 3055RL, 2011 F350 DRW 6.7L 4x4 Diesel Lariat and Hensley TrailerSaver BD3, 1992 Jeep ZJ and 1978 Coleman Concord Pop-Up for remote camping
Dave & Renee plus (Champ, Molly, Paris, Missy, and Maggie in spirit), Mica, Mabel, and Melton