mikemc53,
Slides, like any other system on a motorhome, are subject to failure. Sooner or later, something likely will come up, minor or major, but most folks consider the added space they add to worth the price of admission. Some on here may even recommend to stay away from particular slide manufacturers. I won't comment on the slide in our manufacturer as Georgie Boy is no longer in business. Unless you're looking for 13+ year old units, Georgie Boy won't be on your list.
As to accessibility, that is DEFINITELY something you want to check out. At most shows, you'll notice they have all of the slides OUT. You want to see what the access is when the slides are IN. You are correct is that some units inhibit and even prohibit access to key areas and storage space. We made sure our rig had the access we needed when on the road. If you overnight at rest areas, Walmarts, etc., the general consensus is NOT to put out the slides, unless you can do so where they will not cause a problem to others in the area.
Good Luck in your search!
~Rick
2005 Georgie Boy Cruise Master 3625 DS on a Workhorse W-22
Rick, Gail, 1 girl (27-Angel since 2008), 1 girl (22), 2 boys (23 & 20).
2001 Honda Odyssey, Demco Aluminator tow bar & tow plate, SMI Silent Partner brake controller.