Hi Jeff,
The Ford Transit sure shows a lot of promise. There are some RV manufactures utilizing it, and more to come in due time. Just make sure the brand & model you consider can handle the weight with consideration to fresh water, people, and people stuff. Even more concerning is the added weight of each slide out. I say this because the Transit cannot carry as much as a Sprinter, and the Sprinter can't carry as much as the E350. A short motor home in the 23-25 foot length, the E350 is ideally suited to handle the weight. The Transit.....it's concerning. Just so you understand, the Promaster chassis is worse yet. You can hardly get in and drive off the RV lot without placing the Promaster rig over-weight.
The weight (and cost savings) issue is the reason why the spare tire is not included. That allows ~70 pounds more of your own stuff you can bring along. I am surprised myself to learn how many people do not carry a spare tire. It is much more common than you might think. Tire pressure sensors are "A Must" in my own mind if not carrying a spare. Also carrying a can of Fix-A-Flat wouldn't hurt either.
And the answer is "YES" to your one question. The 6 wheels/tires are identical and can be mounted in any of the 6 positions.
If looking for a rig suited for two people, I kindly introduce you to
THIS line with short models offered on the E350 and Sprinter. We've owned our 2350
HERE for nearly 10 years now which hasn't changed much since.