Had an old guy years ago when I was a kid tell me, "son, I don't think you can get there from here".
Basically, you are going to find a few curves any way you go. The 68 route is the best up to I-75. That 74 route is pretty in an auto but I would tow or take my MH across there.
You could go south on 19 to Blairsville, then west to Hiawassee and then to Clayton and north on 441 to Franklin NC to Silva and Waynesville and go I-40 west thru the gorge up to Knoxville. That would be a huge amount out of the way. No switchbacks but still mountain roads for the most part.
horsedoc
2008 Damon Essence
2013 Jeep Sahara Unlimited
Blue Ox tow