Can't speak about US 52 but a few years back we drove pulling my 30ft 5th Wheel from Sask, down to Spearfish and then onto Deadwood.
Ok going backwards from the USA north we traveled:
started at Spearfish at I-90 headed north on 85 all the way to the Sask ( Canadain) Boader, then north on Sask 35 to Wayburn, then took Hwy 39 to Mooejaw.
There was hardly any traffic and we had a nice peaceful drive.
Soup.
2018 Northern Lite 8-11 EX Dry Bath
2017 Sierra SLE, 3500 HD / 4x4 / Duramax with a 6 speed Allison Trans
Torklift Super Hitch 20K, 48" Super Truss, front and rear frame mounted tie downs
Fast Gun Long Range SS Turnbuckles, Fast Gun locks