It will not be fun in a few spots, but it's doable. I just drove it in my truck a couple of weeks ago, but I wasn't pulling my trailer. Much of it will be fine, but there are some stretches that are very narrow and twisty with blind corners and a rock wall close up against the North Side of the road. You should be able to pull up pictures of the hwy using Google Street View.
Btw- We noticed a plume of smoke from a large fire that has recently flared up north of there near Agnes. That should be far enough away from there to not be an issue, but you may want to check.
If you plan on visiting the Redwoods, consider unhooking the 5th wheel when you get to Jedadiah Smith State Park and driving Howland Hill Road. No trailers are allowed on this dirt road, but it will get you up close and personal with a lot of big redwoods.