Don't know where you're starting in Md, but we always avoid I95 by using U S 301 to miss Baltimore - D C - Richmond - Petersburg mess. South of Petersburg I 95 is comfortable for us.(no tolls yet!) U S 17 is a good bit east of 95 through SC. U S 301 parallels the interstate for most of the state however. Can get very congested and there is construction and sometimes delays. You can take U S 17 through South Carolina, but seems a bit out of the way until almost through the state where 96 and 17 meet around exit 33. 17 has been improved. Almost every mile is now 4 lanes. Also, if you choose, take U S 17(locally called the ByPass)(NOT U S 17 Business (King's Highway) through the Myrtle Beach area. Business is all 'stop and go' with traffic lights on most intersections. I would suggest avoiding it through Charleston as well. I 526 goes around from Mt. Pleasant to just south of the city and it's well worth missing the traffic and narrow 17 there. (no tolls)Took 17 until we hooked back up with 95 around exit 33 around Point South, SC. Stayed on 95 through most of Ga (no tolls) into Florida. Then it all depends on where you're going in Fl. Just took a trip from MB to Ft. Lauderdale and found no problems avoiding interstates when feasible. A1A is still way too congested and narrow for us, with our 32'Class A and toad. Just our experiences.
Two young retirees restless to GO!
Life is too short to wait too long to do all we want to do!!
Go and enjoy!!