One reasonable possibility is US202 to I-91 to I-84 to I-81 to I-77 to I-26 to I-95 to...whatever makes sense. I-91 and I-84 are not always a great treat with congestion and construction and so forth (and I suspect you may already be well aware of that), but from then on I think it's quite a nice route. It might look out of the way on paper, but in terms of time spent traveling I don't think it's much if any longer most of the time.