We towed an E350 based van/motorhome that scaled in at 9700 pounds or so empty...which is how we had to tow it to stay under our 10,000 pound limit. We towed this three times form Canada to Palm Springs and then back. (its a long story). Anyway,
You will know its there.
Use a brake buddy or other braking system.
Every hill will be one gear slower.
Mileage wasn't that much worse.
In our case we had to disconnect the driveshaft every time. Wife installed a bracket beside the driveshaft so all she had to do was remove the 4 driveshaft bolts, lay it in the bracket and fasten it down.
Ours was a bit more of a temporary special situation. Yours sounds a little more permanent. But hey, it should work. Just don't be in a hurry up the hills...or down. We have towed everything with everything so we were comfortable with it.