No. The major effects from all the joint supplements come from chondroitin and glucosamine. To make their product unique, each manufacturer puts in a little different amount of these two things plus "minor ingredients," things like vitamins, minerals, MSM, etc. Some of these ingredients are a little more likely to create symptoms/problems if overdosed while the glucosamin and chondroitin components are very safe even at higher than normal doses.
I've had a few case specific conditions where we did doses about 5-10 times normal therapeutic dose to act as antiflammatory... The ones I remember were onychodystrophy (nails shed and left quick exposed - imagine the pain), and chronic interstitial cystitis (bloody urine that was not caused by infection).
Doug & Sandy
Kaylee
Winnie 6 1/2 year old golden
2008 Southwind 2009 Honda CRV