Lane departure is using cameras mounted on center mirror, so camper is not affecting it.
The blind spots use radars in taillights, so big camper covers them, making unusable.
I removed my tailgate camera, made extension cord for it and mounted on the back of the camper. Works like a charm with 360 coverage.
Even when I drop the camper and drive without tailgate camera, the side cameras are still very helpful.
Just couple days ago I had to find parking in the center of Atlanta. Went into small lot with automatic gates and sharp turns design for cars, not extended dualies. Thanks to front camera I did avoid several stop to see how much space I have in front.