Plan to tow with overdrive locked out. This will help keep your torque converter from generating too much heat (which can damage the transmission). You'll want a good in-cab brake controller; the Tekonsha Prodigy controllers are worth the little bit extra they might cost. Also consider a weight distribution hitch with built-in sway control, such as the Equal-i-zer or Andersen No-Sway (I've used both and preferred the latter, but either one will work).
Plan on driving about 60 mph most of the time, and be willing to slow down on the uphill grades. Anything faster will smack your fuel economy and be a greater strain on the drive train. And try to pick out a TT that minimizes the frontal area (not too tall, not too wide) because wind resistance is the big factor when towing on the highway. I would try to keep the height under 105" (not counting A/C unit) and only 7'-7.5' wide instead of 8', unless it has a more rounded shape (like Airstream).
Mike G.
Liberty is meaningless where the right to utter one's thoughts and opinions has ceased to exist. That, of all rights, is the dread of tyrants. --Frederick Douglass
photo: Yosemite Valley view from Taft Point