It has been 2 (3?) yrs, but we towed our 35' 5er from Branson down US 65, to US 412, to I-49, to I-40, to US 69 to Texas. As far as the tow, no problems at all.
But at the time, there was some pretty rough sections of US 69 between McAlester and Atoka. But I seem to remember reading that it had been repaved since then.