That's one where all it takes is a moment's distraction to miss the interchange.
I use a different route sometimes, I-57 (coming off US-24 from Fort Wayne) to I-74 to US-36 across Missouri. Have to watch two spots. Westbound, miss the turn to I-55, go into the north side of Springfield. Eastbound, can miss the turn to 57 north, go into Champaign. Doesn't even have to be a talking distractions, sign locations are poor, dealing with a traffic situation is enough to miss the exit.
Both of those are pretty easy to sort out, missing a turn in St Louis is messier to fix. I like to take I-255 around to the south, area is still less developed, less local on and off traffic.
Tom Test
Itasca Spirit 29B