It depends on when you are asking about. This time of year the snow doesn't usually stick on the freeways and main roads.
We travel every year to LA and San Diego at Christmas time. And no problems the last 6 years, but there has been some snow on these trips. But, I40 can be closed for a period of time when it snows. You have to get past Flagstaff, AZ to get out of the chances of snow.
From Albuquerque, you can also go down I25 to NM 26 to Deming to I10 and I8 and avoid snow if it is snowing west of Albuquerque. We usually come back from San Diego this way.
Amarillo can also be bad and I don't think have have snow removal equipment.
David
2012 Fleetwood Discovery 40G
2012 Jeep Wrangler Unlimited
2019 Jeep Wrangler Unlimited