It's going to depend on the lift size and trailer model. The picture is my latest set up with a stock Fuzion (axles come flipped on Fuzion's) and a 3 1/"2 lift on 33" tires. Just slightly nose high but nothing to be concerned about. Been going to the dunes for the last 4 years with this and no issues, however more bed rail clearance would be a nice luxury. My previous set up was on my old truck with a 4" lift, 33" tires and a Crossroads toyhauler (axles had to be flipped by independent shop) and gave me about the same clearance. My suggestion is to measure the top of your bed rails, mine are at 60" (if I remember correctly), and then measure the bottom of the trailer hang over when the trailer jacks are leveled on the lot. I wouldn't go under a 5-6" bed clearance.
'06 GMC Duramax 4X4
'12 Fuzion 302
Winter 3 sleds
Summer 3 quads