It's really not that interesting, you just end up with a lot of extra grease to clean off from inside the hub.
After two years, I opened my hubs up, cleaned everything and replaced the bearings just for the heck of it - didn't see anything wrong with them but it's like a $5 part so why not.
I only have a single axle trailer, so a double or triple 5R I can see it being a lot more work - ez lube might win out there.
2013 KZ Sportsmen Classic 200, 20 ft TT
2020 RAM 1500, 5.7 4x4, 8 speed