Like everthing else in RV world-it depends.
How many batteries (2,4,6?), How are they wired together (see next para), How old are they.
First off, I would love to add a graphic but don't have one. Think of a ladder up against a house roof and the batteries are the ladder. If your POS wire is connected at the top left of the ladder and NEG wire is connected at the top right of the ladder THEN the top battery (think rung=battery) will get used more than the battery below it (next rung down). Over time, the batteries will degrade at different rates. Now, if your ladder had the POS wire on the top left of the ladder and NEG was connected at the bottom right of the ladder, each battery will degrade evenly (unless the battery has a defect).
When to Equalize? When the batteries' specific gravity readings (at rest) are not close (how much varies by mfgr). Or you have a specific battery cell that is out of range with the rest on that battery (you MIGHT be able to recover that battery). Equalizing takes time and is best done when your batterys are not being under load or under charge. So I would not equalize my first day at the CG.
Sorry, this doesn't answer your simple question. Can you give us specific gravity readings and maybe we can give you a better answer.
Playtime IV
2006 HR Scepter 42DSQ