That's a pretty good truck to tow anything with. The only thing I don't like about that combo is towing through rush hour stop-and-go traffic! 1st gear is too low to keep up with creeping traffic, then cars take the gap as a cue to cut you off, and 2nd is too tall to stay off the clutch.
My only other tip is long downgrades.... Go down in the same gear you came up, and use the exhaust brake feature. You shouldn't even need your service brakes unless you come up slower traffic or approach sharp curves.
2000 Ford E450 V10 VAN! 450,000+ miles
2014 ORV really big trailer
2015 Ford Focus ST