They both cross the same mountain chain, they both are heavily travelled, they both require (and will have) numerous construction zones.
Depends on whether your need to take a more southern route, outways your need to maintain the thickness of your wallet. Where do you want to enter/exit the state. They meet in OHIO, but they are two different spaces on the east side of the map.
Are you planning on stopping in the state? More choices of camp grounds if you stay north.
Most exits have some sort of services on I-80. Travel plazas on the T/P are few and far between...you will need to exit T/P to reach most conveniences.
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