Someone mentioned that it is 60 miles from one point to the other. It sounds like nothing. At the wrong time of day, though, that trip can take three hours! So that is why the OP is asking.
If you have ever seen the "Californians" skits on Saturday Night Live (available on YouTube), the skits are dead accurate -- in southern Calif, we are very serious about strategies to avoid sitting in traffic.
And now, back on topic. The biggest problem the OP will face is Pacific Coast Highway. It can slow down a lot without warning at any time, if there is a fender bender anywhere along the way. No way to avoid the PCH, unless you take Kanan Dume over the hill back to the 101. Which probably will not save any time.
Good luck!
2012 Fun Finder X-139 "Boondock Style" (axle-flipped and extra insulation)
2013 Toyota Tacoma Off-Road (semi-beefy tires and components)
Our trips -- pix and textAbout our trailer"A journey of a thousand miles begins with a single list."