I often drive from Parkersburg to Columbus for conferences. I go via Rt.50 to US 33. Once I get to Columbus, there are several options such as your planned route around the city, or I can continue on US 33 to downtown - easy for me in a car, but not recommended in an RV.
I live and work just off I77 and prefer going US 33 over I77 to I70 to get to Columbus.
It is a lovely trip on US 33 now that it bypasses Nelsonville. And, I get to stop at the flea markets and oldies diner near Logan.
-Laura
2016 Shasta Oasis 18BH (specs and floor plan in profile)
2015 Ram 1500 Hemi