I did while my daughter was on Mississippi Gulf Coast, may do it again when her husband retires and they move back.
Why? It is closer to my summer locations in the Great Lakes, I don't need winter to be warm, just not cold, and I prefer the culture. I've been 30 years in a small town on the Southern Plains, where culture is very much like The South, particularly in rural areas.
If you are from an urban or metro suburban culture, any major metro area not in the south, you might not like or understand how people behave. So that could be a reason not to go to the Gulf Coast (except Florida where most everybody is from The North anyway).
Tom Test
Itasca Spirit 29B