Except for a couple of short stretches on US 64 and Hwy 12, on the outer banks, you will have 4 lane highways, assuming you choose the I-85 to I-40 route. (Hwy 49 from Charlotte to Raleigh is less distance, but is a lot of two-lane and not as fast.
It's about a 7-hour drive, not counting stops. We could do it in one day, but that's not how we like to travel, especially since we would stop twice to walk the dogs.
In the Rodanthe area you should look at the Hatteras KOA and Camp Hatteras Campgrounds. (Some like the Waves Campground a short distance south of Rodanthe.)
PS. The title of your thread doesn't seem fitted to your questions. A different subject line might draw in more members with direct knowledge of the route.
Tom
2015 Meridian 36M
2006 CR-V toad
3 golden retrievers (Breeze, Jinks, Razz)
1 border collie (Boogie)