A year from now, the new gas class A chassis from Ford will be powered by the new 7.3 V-8. Likely a more torquey (is that a word) engine, along with a new 10 speed tranny.
Word from Ford is a lower and wider torque curve, lower maintenance frequency and cost, and better economy. (end of commercial) To me, the first 2 to three years of a drivetrain are scary until they work out the bugs in the design.
On your Tires/wheels question, If you are using this in part for work in excavating, I would agree to get/look for the bigger wheels to maximize the ground clearance, the longer overall length can open the door to tail or center dragging problems.
If you are using on good roads at all times, I wouldn't worry about it.