We have a 350 HP Cat C7 in a 39' Fleetwood Excursion. We've been to Alaska and back, all through the Rockies in western Canada and up and down the western US twice with no problems. That includes entering the Tetons from the west side (8 miles of 10% grades) Eisenhower Tunnel, and southern Utah - a few 14% grades. Just keep your RPMs up and make sure your radiator and intercooler are clean.
As far as cold weather... If you're in a pick up truck where #1 fuel is being sold, yes you should use Power Serve. It does lower the poor point of diesel, but more important it puts the lubricity back in the fuel that that was lost as part of the process to make #1. The injection pumps in diesel pick-up trucks are very sensitive to lubricity. They're running about $6K to replace and a lot of them get replaced up here every winter. I'm not sure how #1 fuel effects the larger DP engines as far as lubricity goes? I carry several jugs of Power Serve in my DP and if I get to where they're selling #1, I'll use it as cheap insurance.
If you were going to park it in colder weather, yes I'd use Power Serve to help with the starting. Also know how to use your engine pre-heater. And hopefully you will have an engine heater. Find the switch for it, sometimes the mfgs like to hike it. It will run on 120VAC, so you'll need to have the MH plugged in or be able to start the generator to power it. The gen set usually starts easier in cold weather than the main engine does just because it's a smaller engine. Also if it's cold out, and the generator will start, start it to run the main engine heater and at the same time it will raise the charge in the starting batteries. Depending on how cold it is, you may have to let the engine heater run for a couple hours. Once you get used to your engine, you'll be able to tell if it's going to start or needs more heating. In cold weather, if possible, you should also try to park it so that you can get another vehicle close enough to the batteries to jump it.
Bill
Bill
Nodwell RN110 out moose hunting. 4-53 Detroit, Clark 5 spd, 40" wide tracks, 10:00x20 tires, 16,000# capacity, 22,000# weight. You know the mud is getting deep when it's coming in the doors.