If that is the E450 SuperDuty cutaway series, it is probably the same combo as our 06, V10 with the 5 spd Torque shift transmission. We have not had any problems with the engine or transmission. Adequate power for our 29' pulling the CRV.
Others have reported this combination engine and transmission bullet proof.
Our only chassis work done was the brakes, other than regular maintenance.
Ken
2006 Winnebago Outlook 29B E-450.
2012 Honda CR-V AWD
Blue Ox Aventa LX tow bar and Brake Buddy Vantage.