Giving a hint of what year, brand/model of RV (and water heater) you've got would help immensely in trying to determine where your fault might be.
All I know from your post is that you replaced a "fuse". Because breakers have been used for so long on the 120v circuits, the fuse must be in a 12 volt circuit. That make sense because more than one appliance quit when it blew. The 12 volt is used for the control panels of the air conditioner and the water heater. The fact your problem occurs when you turn on your electric water heater element sounds like the separate 120v circuit to the water heater is somehow shorting out the 12v to the water heater. Open the water heater and make sure there's no sign of any wires touching each other. This is just a guess based on the information you've given so far.
Don Ford
2004 Safari Trek 31SBD (F53/V10 20,500GVW)
'09 HHR 2LT or '97 Aerostar MiniVan (Remco driveshaft disconnect) for Towed vehicles
BlueOx Aventa II Towbar - ReadyBrake Inertia Brake System